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KMID : 0043320140370070941
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Archives of Pharmacal Research
2014 Volume.37 No. 7 p.941 ~ p.954
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Secondary metabolites isolated from Castilleja rubra exert anti-inflammatory effects through NF-κB inactivation on lipopolysaccharide-induced RAW264.7 macrophages
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Lee Dong-Sung
Keo Samell
Ko Won-Min
Kim Kyoung-Su
Ivanova Elena
Yim Joung-Han
Kim Youn-Chul
Oh Hyun-Cheol
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Abstract
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8-Epiloganin (1), mussaenoside (2), and 5-O-caffeoylshikimic acid (3) have been isolated from Castilleja rubra, and the anti-inflammatory properties of these metabolites in a cell culture system were investigated. Compounds 1?3 suppressed not only the production of nitric oxide (NO) and prostaglandin E2, but also the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysaccharide (LPS) in the RAW264.7 murine macrophage cell line. Compounds 1?3 also inhibited the release of pro-inflammatory cytokines induced by LPS, namely, tumor necrosis factor-α and interleukin-1β. The underlying mechanism of the anti-inflammatory action of compounds 1?3 was associated with downregulation of nuclear factor-κB.
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KEYWORD
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Castilleja rubra, 8-Epiloganin, Mussaenoside, 5-O-Caffeoylshikimic acid, Anti-inflammation, Nuclear factor-κB
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